And it says the move will result in lower prices for customers in its pubs.
The pubs will stop serving Jagermeister (a herbal liqueur from Germany), as well as French brandies Courvoisier VS and Hennessy Fine de Cognac from September 26.
They will be replaced with E&J Brandy (the number two selling brandy in the USA), Black Bottle (the number one selling brandy in Australia) and Strika, a herbal liqueur produced in England.
E&J Brandy and Strika will be available in all Wetherspoon pubs from September 26, while Black Bottle will be available from the start of November.
Wetherspoon has already replaced Champagne with sparkling wines from the UK and Australia in its pubs as well as German wheat beers with those from the UK.
Wetherspoon founder and chairman, Tim Martin, said: “ The three new products will be offered at a lower price than those they are replacing.
“This is a significant move by us and highlights our commitment to offering an excellent range of UK and world products, with the emphasis on quality and value for the two million customers who visit our pubs each week.
“In blind tastings conducted by Wetherspoon, the new products were more popular than those they are replacing.
“We will continue to review all products over the next 24 months, with the object of making the business more competitive and offering the best choice and value for customers.
“Many commentators talk of a “cliff-edge” if the UK “crashes out” of the EU without a deal.
“In reality, there is no cliff-edge, only sunlit uplands beyond the EU’s protectionist system of quotas and tariffs.
“All EU products have UK or non-EU replacements, often at equal or better quality and price.
“It’s important to remember that 93 per cent of the world is outside the EU.”